Identification of proteome-based immune subtypes of early hepatocellular carcinoma and analysis of potential metabolic drivers

In this study, we used a proteomic dataset to identify three immune subtypes (IM1-IM3) in HCC, each of which has distinctive clinical, immune, and metabolic characteristics. Among these subtypes, IM3 was found to have the poorest prognosis, with the highest levels of immune infiltration and T-cell exhaustion. Furthermore, IM3 showed elevated glycolysis and reduced bile acid metabolism, which was strongly correlated with CD8 T cell exhaustion and regulatory T-cell accumulation. Our study presents the proteomic immune stratification of HCC, revealing the possible link between immune cells and reprogramming of HCC glycolysis and bile acid metabolism, which may be a viable therapeutic strategy to improve HCC immunotherapy.PMID:38008179 | DOI:10.1016/j.mcpro.2023.100686
Source: Molecular and Cellular Proteomics : MCP - Category: Molecular Biology Authors: Source Type: research