Role of soluble epoxide hydrolase in the abnormal activation of fibroblast-like synoviocytes from patients with rheumatoid arthritis

In this study, we report elevated sEH expression in the joints of CIA (collagen-induced arthritis) rats, concomitant with diminished levels of two significant EpFAs. Additionally, increased sEH expression was detected in both the synovium of CIA rats and in the synovium and fibroblast-like synoviocytes (FLS) of RA patients. The sEH inhibitor TPPU attenuated the migration and invasion capabilities of FLS derived from RA patients and to reduce the secretion of inflammatory factors by these cells. Our findings indicate a pivotal role for sEH in RA pathogenesis and suggest that sEH inhibitors offer a promising new therapeutic strategy for managing RA.PMID:38013165 | DOI:10.1016/j.clim.2023.109850

Source: Clinical Immunology - November 28, 2023 Category: Allergy & Immunology Authors: Yaoyu Pu Ruijuan Cheng Qiuping Zhang Tianwen Huang Chenyang Lu Zhigang Tang Yutong Zhong Liang Wu Bruce D Hammock Kenji Hashimoto Yubin Luo Yi Liu Source Type: research