Clinical whole-genome sequencing and FISH identify two different fusion partners for NUP98 in a patient with acute myeloid leukemia: a case report

Only rare cases of acute myeloid leukemia (AML) have been shown to harbor a t(8;11)(p11.2;p15.4). This translocation is believed to involve the fusion of NSD3 or FGFR1 with NUP98; however, apart from targeted mRNA quantitative PCR analysis, no molecular approaches have been utilized to define the chimeric fusions present in these rare cases.

Source: Cancer Genetics and Cytogenetics - November 29, 2023 Category: Genetics & Stem Cells Authors: Bahareh A. Mojarad, Zachary D. Crees, Molly C. Schroeder, Zhifu Xiang, Justin Vader, Jason Sina, Meagan Jacoby, John L. Frater, Eric J. Duncavage, David H. Spencer, Kory Lavine, Julie A. Neidich, Ina Amarillo Tags: Case Report Source Type: research