Early versus Late Caffeine Therapy Administration in Preterm Neonates: An Updated Systematic Review and Meta-Analysis

CONCLUSION: As compared with late caffeine administration, early caffeine is associated with a reduction in BPD, IVH, ROP, late-onset sepsis, and PDA in preterm neonates, albeit increased mortality. Additional RCTs are warranted to confirm these findings and evaluate whether the effect on mortality may be related to survival bias in observational studies favoring the late treatment group.PMID:37989113 | DOI:10.1159/000534497

Source: Neonatology - November 21, 2023 Category: Perinatology & Neonatology Authors: Vanessa Karlinski Vizentin Isabela Madeira de S á Pacheco Thalita Fahel Vilas B ôas Azevêdo Cynthia Flor êncio de Mesquita Rafael Alvim Pereira Source Type: research