Nighttime administration of antihypertensive medication: a review of chronotherapy in hypertension

Korean J Intern Med. 2023 Nov 16. doi: 10.3904/kjim.2023.304. Online ahead of print.ABSTRACTHypertension remains a global health concern because of suboptimal blood pressure control despite advancements in antihypertensive treatments. Chronotherapy, defined as evening or bedtime administration of medication based on biological rhythms, is emerging as a potential strategy to improve blood pressure control and treatment outcomes. Clinical trials have investigated the potential effects of nighttime administration of antihypertensive medication in the improvement of 24 hours blood pressure control and reduction of cardiovascular risk. Implementing chronotherapy in clinical practice could have significant implications in enhancing blood pressure control and improving clinical outcomes in patients with hypertension, particularly those with resistant hypertension. However, recent trials have reported contradictory results, causing confusion in real-world practice. Herein we review, analyze, and critique the current evidence and propose suggestions regarding the clinical application and future directions of chronotherapy.PMID:37967524 | DOI:10.3904/kjim.2023.304
Source: The Korean Journal of Internal Medicine - Category: Internal Medicine Authors: Source Type: research