Novel ACTL7A variants in males lead to fertilization failure and male infertility

ConclusionACTL7A variants affected the expression and localization of actin-like protein 7A in the affected spermatozoa and subsequently decreased the expression of phospholipase C zeta 1, which caused fertilization failure and male infertility.

Source: Andrology - November 23, 2023 Category: Urology & Nephrology Authors: Meng Wang, Juepu Zhou, Rui Long, Huizi Jin, Limin Gao, Lixia Zhu, Lei Jin Tags: ORIGINAL ARTICLE Source Type: research