Sarcoid Uveitis in Children

Ocul Immunol Inflamm. 2023 Nov 20:1-6. doi: 10.1080/09273948.2023.2282609. Online ahead of print.ABSTRACTSarcoidosis is a multi-system granulomatous disease that often presents with uveitis. Although sarcoidosis and sarcoid uveitis typically occur in adulthood, children also may be affected. There are two distinct clinical presentations of the pediatric disease, associated with younger and older age groups, and having different causations. "Early-onset sarcoidosis", beginning at age 5 years or less, is an autosomal dominant genetic disease, caused by a mutation in the NOD2 gene. It is also known as sporadic Blau syndrome or Jabs syndrome. "Adult-type sarcoidosis", usually beginning between the ages of 8 and 15 years, is believed to represent an excessive response to an environmental antigen. There is limited literature on the management of pediatric sarcoidosis, and treatment follows an approach applied to other forms of pediatric non-infectious uveitis. When systemic immunomodulatory therapy is indicated, methotrexate and/or adalimumab are often employed. The condition may persist into adulthood, and thus long-term follow-up is indicated.PMID:37983819 | DOI:10.1080/09273948.2023.2282609

Source: Ocular Immunology and Inflammation - November 20, 2023 Category: Allergy & Immunology Authors: Justine R Smith Manabu Mochizuki Source Type: research