Gut-derived ammonia contributes to alcohol-related fatty liver development via facilitating ethanol metabolism and provoking ATF4-dependent de novo lipogenesis activation

Dysbiosis contributes to alcohol-associated liver disease (ALD); however, the precise mechanisms remain elusive. Given the critical role of the gut microbiota in ammonia production, we herein aim to investigate whether and how gut-derived ammonia contributes to ALD.

Source: Metabolism - Clinical and Experimental - November 21, 2023 Category: Biomedical Science Authors: Qing Song, Chueh-Lung Hwang, Yanhui Li, Jun Wang, Jooman Park, Samuel M. Lee, Zhaoli Sun, Jun Sun, Yinglin Xia, Natalia Nieto, Jose Cordoba-Chacon, Yuwei Jiang, Xiaobing Dou, Zhenyuan Song Source Type: research