Genomics, Transcriptomics, and Epigenetics of Sporadic Pituitary Tumors
Arch Med Res. 2023 Nov 17:102915. doi: 10.1016/j.arcmed.2023.102915. Online ahead of print.ABSTRACTPituitary tumors (PT) are highly heterogeneous neoplasms, comprising functioning and nonfunctioning lesions. Functioning PT include prolactinomas, causing amenorrhea-galactorrhea in women and sexual dysfunction in men; GH-secreting adenomas causing acromegaly-gigantism; ACTH-secreting corticotrophinomas causing Cushing disease (CD); and the rare TSH-secreting thyrotrophinomas that result in central hyperthyroidism. Nonfunctioning PT do not result in a hormonal hypersecretion syndrome and most of them are of gonadotrope differentiation; other non-functioning PT include null cell adenomas and silent ACTH-, GH- and PRL-adenomas. Less than 5% of PT occur in a familial or syndromic context whereby germline mutations of specific genes account for their molecular pathogenesis. In contrast, the more common sporadic PT do not result from a single molecular abnormality but rather emerge from several oncogenic events that culminate in an increased proliferation of pituitary cells, and in the case of functioning tumors, in a non-regulated hormonal hypersecretion. In recent years, important advances in the understanding of the molecular pathogenesis of PT have been made, including the genomic, transcriptomic, epigenetic, and proteomic characterization of these neoplasms. In this review, we summarize the available molecular information pertaining the oncogenesis of PT.PMID:37981525 | DOI:10.1...
Source: Cell Research - Category: Cytology Authors: Daniel Marrero-Rodr íguez Sandra Vela-Pati ño Florencia Martinez-Mendoza Alejandra Valenzuela-Perez Eduardo Pe ña-Martínez Amayrani Cano-Zaragoza Jacobo Kerbel Sergio Andonegui-Elguera Shimon S Glick-Betech Karla X Hermoso-Mier Sophia Mercado-Medrez A Source Type: research
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