The phase variation between wrinkly and smooth colony phenotype affects the virulence of Vibrio parahaemolyticus

In this study, the data showed that the smooth spreader had stronger virulence phenotypes, including the cytotoxicity against HeLa cells, antibacterial activity against E. coli, adhesive capacity toward HeLa cells, and lethality in zebrafish, relative to the wrinkly one. However, the colony morphology variation had no influence on the haemolytic activity. The mRNA levels of major virulence genes including T3SS1, T6SS1, and T6SS2 were significantly enhanced in the smooth colonies relative to those in the wrinkly colonies. Taken together, the presented work highlighted the different virulence profiles of the wrinkly and smooth colony phenotypes.PMID:37973623 | DOI:10.1007/s00203-023-03719-1
Source: Archives of Microbiology - Category: Microbiology Authors: Source Type: research