Efficacy and Safety of Repetitive Transcranial Magnetic Stimulation in Spinocerebellar Ataxia Type 3: a Systematic Review and Meta ‑analysis of Randomized Controlled Trials

AbstractTherapeutic alternatives for spinocerebellar ataxia type 3 (SCA3) are limited. Repetitive transcranial magnetic stimulation (rTMS) as a potential intervention has drawn heightened interest because of its ease of implementation, cost-effectiveness, and safety profile. We conducted a systematic review and meta-analysis to evaluate the efficacy of rTMS in the treatment of SCA3. We systematically searched databases —PubMed, Embase, the Cochrane Library, and Springer—for randomized controlled trials (RCTs) investigating the use of rTMS in the treatment of SCA3. Major efficacy outcomes were assessed, including International Cooperative Ataxia Rating Scale (ICARS) scores, Scale for the Assessment and Rating o f Ataxia (SARA) scores, and ICARS subscale scores. Six randomized controlled trials involving 175 patients were included in the analysis. The meta-analysis results indicated statistically significant increases in ICARS (mean difference (MD) =  − 3.88, 95% confidence interval (CI) =   − 7.46 to − 0.30;p = 0.03) and SARA (MD of − 1.59, 95% CI − 2.99 to − 0.19;p = 0.03) scores. No significant heterogeneity was observed across all outcomes (I2 = 0%). Dynamic function within the ICARS scale markedly improved with rTMS (MD =  − 2.19, 95% CI =  − 3.82 to − 0.55;p = 0.009). The majority of the included studies exhibited a low risk of bias, and no severe adverse reactions were noted. Our me...
Source: The Cerebellum - Category: Neurology Source Type: research