Inhibitory effect of trans-tiliroside on very low-density lipoprotein secretion in HepG2 cells and mouse liver

AbstractAn acylated flavonol glycoside,trans-tiliroside (1), is found in certain parts of different herbs, including the seeds ofRosa canina (Rosaceae). Previous studies on compound1 have focused on triglyceride (TG) metabolism, including its anti-obesity and intracellular TG reduction effects. In the present study, the effects of compound1 on cholesterol (CHO) metabolism were investigated using human hepatocellular carcinoma-derived HepG2 cells and mice. Compound1 decreased CHO secretion in HepG2 cells, which was enhanced by mevalonate in a concentration-dependent manner and decreased the secretion of apoprotein B (apoB)-100, a marker of very low-density lipoprotein (VLDL). Compound1 also inhibited the activity of microsomal triglyceride transfer proteins, which mediate VLDL formation from cholesterol and triglycerides in the liver. In vivo, compound1 inhibited the accumulation of Triton WR-1339-induced TG in the blood of fasted mice and maintained low levels of apoB-100. These results suggest that compound1 inhibits the secretion of CHO as VLDL from the liver and has the potential for use for the prevention of dyslipidemia.Graphical abstract
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research