Non ‐invasive in vivo measurements of metabolic alterations in the type 2 diabetic brain by 1H magnetic resonance spectroscopy

Choi et  al. present a1H magnetic resonance spectroscopy (MRS) study to delineate the effect of poorly controlled chronic hyperglycemia from type 2 diabetes (T2D) on neurochemical profiles in humans and mice. Brain glucose levels were higher in humans cross-sectionally and animals longitudinally in addition to taurine, glucose+taurine,myo-inositol, and choline-containing compounds compared with controls. Overall, this study demonstrates hyperglycemia-induced changes in neurochemicals that serve a suite of biological functions, including as neurotransmitters, bioenergetic substrates, organic osmolytes, and messenger molecules. Paired neurochemical plots show reliable separation of the diabetic group from controls with brain regional differences during disease progression. AbstractType 2 diabetes (T2D) is a complex chronic metabolic disorder characterized by hyperglycemia because of insulin resistance. Diabetes with chronic hyperglycemia may alter brain metabolism, including brain glucose and neurotransmitter levels; however, detailed, longitudinal studies of metabolic alterations in T2D are lacking. To shed insight, here, we characterized the consequences of poorly controlled hyperglycemia on neurochemical profiles that reflect metabolic alterations of the brain in both humans and animal models of T2D. Using in  vivo1H magnetic resonance spectroscopy, we quantified 12 metabolites cross-sectionally in T2D patients and 20 metabolites longitudinally in T2Ddb/db mice versusdb+ c...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research