Treatment with recombinant Sirt1 rewires the cardiac lipidome and rescues diabetes-related metabolic cardiomyopathy

Metabolic cardiomyopathy (MCM), characterized by intramyocardial lipid accumulation, drives the progression to heart failure with preserved ejection fraction (HFpEF). Although evidence suggests that the mammal...

Source: Cardiovascular Diabetology - November 13, 2023 Category: Cardiology Authors: Sarah Costantino, Alessandro Mengozzi, Srividya Velagapudi, Shafeeq Ahmed Mohammed, Era Gorica, Alexander Akhmedov, Alessia Mongelli, Nicola Riccardo Pugliese, Stefano Masi, Agostino Virdis, Andreas H ülsmeier, Christian Matthias Matter, Thorsten Hornema Tags: Research Source Type: research