No evidence of genetic causal association between sex hormone-related traits and systemic lupus erythematosus: A two-sample Mendelian randomization study

ConclusionsOur MR analysis demonstrated that genetically predicted testosterone, E2, SHBG, and BT levels were not associated with SLE risk, but the roles of other non-genetic pathways cannot be ruled out.Key Points•This is the first MR study to explore the causal association of sex hormone-related traits with SLE.•No evidence to support causal associations between sex hormone-related traits and SLE.•Our MR analysis may provide novel insights into the causal association between sex hormone-related traits and SLE risk.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research