Relationship of Morphometrics and Symptom Severity in Female Type I Chiari Malformation Patients with Biological Resilience

Cerebellum. 2023 Nov 7. doi: 10.1007/s12311-023-01627-0. Online ahead of print.ABSTRACTIn the present study we report the relationship among MRI-based skull and cervical spine morphometric measures as well as symptom severity (disability-as measured by Oswestry Head and Neck Pain Scale and social isolation-as measured by the UCLA Loneliness scale) on biomarkers of allostatic load using estrogen, interleukin-6, C-reactive protein, and cortisol in a sample of 46 CMI patients. Correlational analyses showed that McRae line length was negatively associated with interleukin-6 and C-reactive protein levels, and Analysis of Variance (ANOVA) showed joint effects of morphometric measures (McRae line length, anterior CSF space) and symptom severity (disability and loneliness) on estrogen and intereukin-6 levels. These results are consistent with allostatic load. That is, when the combination of CSF crowding and self-report symptom (disability and loneliness) severity exceed the capacity of biological resilience factors, then biomarkers such as neuroprotective estrogen levels drop, rather than rise, with increasing symptom severity.PMID:37935987 | DOI:10.1007/s12311-023-01627-0

Source: Cerebellum - November 7, 2023 Category: Neuroscience Authors: Mohamad Motaz Al Samman Monica A Garcia Maitane Garc ía James R Houston Dorothy Loth Richard Labuda Sarel Vorster Petra M Klinge Francis Loth Douglas L Delahanty Philip A Allen Source Type: research