Activation and Denitrosylation of Procaspase-3 in KA-induced Excitotoxicity

CONCLUSIONS: KA led to denitrosylation and activation of procaspase-3 via FasL and TrxR. Inhibition of procaspase-3 denitrosylation by auranofin, SNP, and GSNO played protective effects against KA-induced apoptosis-like neuronal death in rat hippocampal CA1 and CA3 subfields. These investigations revealed that the procaspase-3 undergoes an initial denitrosylation process before becoming activated, providing valuable insights into the underlying mechanisms and possible treatment of excitotoxicity.PMID:37921157 | DOI:10.2174/0109298665261164231019043521
Source: Protein and Peptide Letters - Category: Biochemistry Authors: Source Type: research