Cytokines in Chronic Rhinosinusitis: Role in Eosinophilia and Aspirin Exacerbated Respiratory Disease.

CONCLUSIONS: CRSwNP was characterized by a predominant type-2 inflammatory environment while CRSsNP did not reflect a classic type-1 milieu, as has been previously suggested. AERD can be distinguished from CRSwNP by elevated ECP levels, but this enhanced eosinophilia is not associated with elevations in traditional type-2 inflammatory mediators associated with eosinophil proliferation and recruitment. However, other factors including GM-CSF, MCP-1, and t-PA may be important contributors to AERD pathogenesis.
PMID: 26067893 [PubMed - as supplied by publisher]

Source: American Journal of Respiratory and Critical Care Medicine - June 11, 2015 Category: Respiratory Medicine Authors: Stevens WW, Ocampo CJ, Berdnikovs S, Sakashita M, Mahdavinia M, Suh L, Takabayashi T, Norton JE, Hulse KE, Conley DB, Chandra RK, Tan BK, Peters AT, Grammer Iii LC, Kato A, Harris KE, Carter RG, Fujieda S, Kern RC, Schleimer RP Tags: Am J Respir Crit Care Med Source Type: research