[18F]-FDG uptake in brain slices prepared from an aged mouse model of Alzheimer ’s disease using a dynamic autoradiography technique

ConclusionNeuronal damage, and induction of neuronal apoptosis, decreased [18F]-FDG uptake, increased A β accumulation and P-tau induced neurofibrillary degeneration are observed in AD mouse. In clinical diagnosis, reduction of [18F]-FDG uptake by PET is one of the means of diagnosing the onset of AD. Our results suggest that decreased uptake of [18F]-FDG in the brains of AD may be associated with neuronal dysfunction and cell death in the brain.
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research