Mitochondrial complexome and import network

Trends Cell Biol. 2023 Oct 30:S0962-8924(23)00208-8. doi: 10.1016/j.tcb.2023.10.004. Online ahead of print.ABSTRACTMitochondria perform crucial functions in cellular metabolism, protein and lipid biogenesis, quality control, and signaling. The systematic analysis of protein complexes and interaction networks provided exciting insights into the structural and functional organization of mitochondria. Most mitochondrial proteins do not act as independent units, but are interconnected by stable or dynamic protein-protein interactions. Protein translocases are responsible for importing precursor proteins into mitochondria and form central elements of several protein interaction networks. These networks include molecular chaperones and quality control factors, metabolite channels and respiratory chain complexes, and membrane and organellar contact sites. Protein translocases link the distinct networks into an overarching network, the mitochondrial import network (MitimNet), to coordinate biogenesis, membrane organization and function of mitochondria.PMID:37914576 | DOI:10.1016/j.tcb.2023.10.004
Source: Trends in Cell Biology - Category: Cytology Authors: Source Type: research