Single-cell characterization of macrophages in uveal melanoma uncovers transcriptionally heterogeneous subsets conferring poor prognosis and aggressive behavior

Experimental & Molecular Medicine, Published online: 01 November 2023; doi:10.1038/s12276-023-01115-9A recent study utilized single-cell transcriptome data to explore the cellular heterogeneity of macrophages within the uveal melanoma (UM) tumor microenvironment, revealing four distinct macrophage subsets. One subset, MΦ-C4, was found to be associated with aggressive tumor behavior and poor survival outcomes. The study also developed a machine-learning-based subtyping system to classify UM subtypes and predict prognosis based on MΦ-C4-specific core metagenes. This research deepens our understanding of cellular heterogeneity in UM and highlights the potential therapeutic benefits of targeting macrophages in UM treatment.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research