39. Genomic microarray analysis reveals heterogeneity in high hyperdiploid B-cell acute lymphoblastic leukemia

High hyperdiploidy (HHD) is the most common cytogenetic abnormality in childhood B-cell acute lymphoblastic leukemia (B-ALL) and is generally associated with a favorable prognosis; however, 10-20% of patients with HHD B-ALL will ultimately relapse. Although certain trisomy combinations including chromosomes 4, 10, 17 and 18 have previously been reported to be associated with a superior outcome, recent studies redefined the relapse predictive chromosome trisomy combination. The role of clonal heterogeneity has become important for predicting outcomes in HHD B-ALL.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research