65. Insights into the genetic heterogeneity of glioblastoma: gene amplification in ecDNA and HSR

Glioblastoma is a highly aggressive brain tumor characterized by genetic heterogeneity and a poor prognosis. Novel mechanisms of gene amplification occur most frequently in glioblastoma, involving extrachromosomal DNA (ecDNA) and homogeneously staining regions (HSR), compared to other human tumor types. ecDNA and HSR are circular DNA fragments and chromosomal regions that contain multiple copies of a particular oncogene, respectively. These genetic abnormal structures are thought to facilitate rapid and extensive gene amplification, leading to the upregulation of oncogenes that promote tumor growth and survival.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research