70. Epigenetic reprogramming in thalamic H3K27-altered glioma neural progenitor cells

H3K27-altered diffuse midline gliomas (DMGs) are devastating cancers occurring mainly in young children in the thalamus and brainstem, characterized by a mutation which inhibits the polycomb repressive complex 2 (PRC2) and the resultant widespread loss of the repressive histone modification H3K27me3. H3K27me3 is essential for lineage differentiation. We assembled a single cell dataset from the normal human prenatal and young adult thalamus to better understand the precise regional and developmental origins of these thalamic tumors.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research