70. Epigenetic reprogramming in thalamic H3K27-altered glioma neural progenitor cells
H3K27-altered diffuse midline gliomas (DMGs) are devastating cancers occurring mainly in young children in the thalamus and brainstem, characterized by a mutation which inhibits the polycomb repressive complex 2 (PRC2) and the resultant widespread loss of the repressive histone modification H3K27me3. H3K27me3 is essential for lineage differentiation. We assembled a single cell dataset from the normal human prenatal and young adult thalamus to better understand the precise regional and developmental origins of these thalamic tumors.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Allison Cheney, Yuanqing (Bianca) Xue, A. Geoffrey Lyle, Ellen T. Kephart, Josh M. Stuart, Olena M. Vaske Source Type: research
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