Astrocytic phagocytosis of myelin debris and reactive characteristics in vivo and in vitro

CONCLUSIONS: The results suggested that myelin phagocytosis of astrocytes should help improve the microenvironment and promote myelin regeneration by increasing CNTF and bFGF within the central nervous system.SIGNIFICANCE: However, the molecular interaction of astrocytes acting as phagocytes remains to be further explored. Therefore, an improvement of astrocytes to phagocytize myelin debris may be a promising treatment measure to prevent demyelination and promote remyelination in MS and other diseases with prominent myelin injury.PMID:37851997 | DOI:10.1111/boc.202300057
Source: Biology of the Cell - Category: Cytology Authors: Source Type: research