Sea-blue histiocytosis

Ann Pathol. 2023 Oct 19:S0242-6498(23)00202-X. doi: 10.1016/j.annpat.2023.10.001. Online ahead of print.ABSTRACTA 78-year-old woman with hypertrophic cardiomyopathy underwent a septal myomectomy and valve replacement. In the immediate postoperative period she developed shock of mixed etiology and died. At autopsy, hepatomegaly and splenomegaly were identified, with PAS and Giemsa positive intracellular ceroid granular deposits. Sea-blue histiocytosis is an extremely rare, chronic and benign deposit disease. It is characterized by hepatosplenomegaly, thrombocytopenia and lymphadenopathy. The presence of ceroid substance in granules in PAS and Giemsa stains should establish the diagnosis of suspicion.PMID:37865572 | DOI:10.1016/j.annpat.2023.10.001
Source: Annales de Pathologie - Category: Pathology Authors: Source Type: research