Determination of the elimination half-life of Glyphosate and its main metabolite, AMPA, in chicken plasma

In this study, toxicokinetic parameters for glyphosate and AMPA were calculated after one unique dietary exposure (40 mg of glyphosate equivalent per kg) and one unique intravenous injection of a GBH, in hens and roosters respectively. Non compartmental analysis was used to show the evolution of glyphosate and AMPA plasma concentrations over time. After one unique intravenous injection of a glyphosate-based herbicide, glyphosate and AMPA were quickly eliminated from plasma and were poorly distributed (Vssglyphosate = 0.30 L/kg). Their terminal half-lives are 4.7 h and 8.10 h, respectively. After dietary exposure, glyphosate and AMPA followed a 6 h absorption phase followed by a 42 h elimination phase. They were poorly distributed (Vssglyphosate = 0.00562 L/kg), and their maximum concentrations (Cmax) were 21285 µg/L and 108 µg/L, respectively. Their terminal elimination half-lives were 8.94 h and 6.93 h, respectively. Taken together, this study provides new data on the elimination rate and approximate biological half-life range of glyphosate in birds.PMID:37866553 | DOI:10.1016/j.toxlet.2023.10.009

Source: Toxicology Letters - October 22, 2023 Category: Toxicology Authors: Mathias Fr éville J érôme Henri Anthony Estienne Lo ïse Serra Christelle Ram é Patrice Ganier Marine Chahnamian Pascal Froment Jo ëlle Dupont Source Type: research