Understanding Choroidal Nevus Risk Factors for Transformation into Melanoma

Choroidal nevus is a common intraocular tumor in the United States, found in approximately 5% of Caucasian adults. The three main risks of melanocytic choroidal nevus include vision loss from subfoveal nevus, development of subretinal fluid, and transformation of nevus into melanoma, a malignant counterpart. In this review, we will explore clinical risk factors that predict benign melanocytic choroidal nevus transformation into malignant choroidal melanoma. Based on a large analysis of 2,355 cases that were monitored longitudinally using multimodal imaging, the most recent list of clinical features include tumor Thickness greater than 2 millimeters (mm) on ultrasonography, subretinal Fluid on optical coherence tomography, Symptomatic vision loss 20/50 or worse, Orange pigment on fundus autofluorescence, Melanoma hollow on ultrasonography, and DIaMeter greater than 5 mm on fundus photography.
Source: Clinics in Dermatology - Category: Dermatology Authors: Source Type: research