The interaction between alpha-synuclein and mitochondrial dysfunction in Parkinson's disease

Biophys Chem. 2023 Oct 10;303:107122. doi: 10.1016/j.bpc.2023.107122. Online ahead of print.ABSTRACTParkinson's disease (PD) is an aging-associated neurodegenerative disorder with the hallmark of abnormal aggregates of alpha-synuclein (α-syn) in Lewy bodies (LBs) and Lewy neurites (LNs). Currently, pathogenic α-syn and mitochondrial dysfunction have been considered as prominent roles that give impetus to the PD onset. This review describes the α-syn pathology and mitochondrial alterations in PD, and focuses on how α-syn interacts with multiple aspects of mitochondrial homeostasis in the pathogenesis of PD.PMID:37839353 | DOI:10.1016/j.bpc.2023.107122
Source: Biophysical Chemistry - Category: Chemistry Authors: Source Type: research