Applied physiologically ‐based pharmacokinetic modeling to assess uridine diphosphate‐glucuronosyltransferase‐mediated drug–drug interactions for Vericiguat

This study is a first cornerstone to qualify the PK- Sim platform for use of UGT-mediated DDI predictions, including PBPK models of perpetrators, such as mefenamic acid and atazanavir, and sensitive UGT substrates, such as dapagliflozin and raltegravir.

Source: CPT: Pharmacometrics and Systems Pharmacology - October 12, 2023 Category: Drugs & Pharmacology Authors: Sebastian Frechen, Ibrahim Ince, Andr é Dallmann, Michael Gerisch, Natalia A. Jungmann, Corina Becker, Maximilian Lobmeyer, Maria E. Trujillo, Shiyao Xu, Rolf Burghaus, Michaela Meyer Tags: ARTICLE Source Type: research