Epicardial placement of human placental membrane protects from heart injury in a swine model of myocardial infarction

We present comprehensive transcriptome and proteome profiles of infarct (IZ), border (BZ), and remote (RZ) zone punch biopsies from swine myocardium during the proliferative cardiac repair phase 14 days post-MI. Both HPAC-treated and untreated tissues showed regional dynamic respons es, whereas only HPAC-treated IZ revealed active immune and extracellular matrix remodeling. Decreased endoplasmic reticulum (ER)-dependent protein secretion and increased antiapoptotic and anti-inflammatory responses were measured in HPAC-treated biopsies. We provide quantitative evidence HPAC redu ced cardiac injury from MI in a preclinical swine model, establishing a potential new therapeutic strategy for IRI. Minimizing the impact of MI remains a central clinical challenge. We present a new strategy to attenuate post-MI cardiac injury using HPAC in a swine model of IRI. Placement of HPAC me mbrane on the heart following MI minimizes ischemic damage, preserves cardiac function, and promotes anti-inflammatory signaling pathways.

Source: Physiological Reports - October 18, 2023 Category: Physiology Authors: Rinku S. Skaria, Marissa A. Lopez ‐Pier, Brij S. Kathuria, Christian J. Leber, Paul R. Langlais, Shravan G. Aras, Zain I. Khalpey, Pamela G. Hitscherich, Evangelia Chnari, Marc Long, Jared M. Churko, Raymond B. Runyan, John P. Konhilas Tags: ORIGINAL ARTICLE Source Type: research