Could Immune Checkpoint Disorders and EBV Reactivation Be Connected in the Development of Hematological Malignancies in Immunodeficient Patients?

In conclusion, our study underscores the intricate relationship between immune dysfunction, EBV reactivation, and immune checkpoint modulation in the context of immunodeficiency-associated cancers. The altered expression of immune checkpoints, along with heightened EBV reactivation, suggests a potential mechanism for immune evasion and tumor progression. These findings provide insights into the complex interactions that contribute to cancer development in immunocompromised individuals, shedding light on potential therapeutic targets for improved management and treatment outcomes. Further investigations are warranted to elucidate the underlying mechanisms and to explore potential interventions to mitigate cancer risk in these patient populations.PMID:37835480 | DOI:10.3390/cancers15194786

Source: Cancer Control - October 14, 2023 Category: Cancer & Oncology Authors: Paulina Mertowska Sebastian Mertowski Konrad Smolak Gabriela Kita Katarzyna Guz Aleksandra Kita Marcin Pasiarski Jolanta Smok-Kalwat Stanis ław Góźdź Ewelina Grywalska Source Type: research