Issue Information

Front coverTraumatic brain injury (TBI) is one of the leading causes of disability and mortality and causes significant neurological and degenerative changes. Primary injury in TBI consists of distinct neuroanatomical zones termed as contusion (Ct) and pericontusion (PC). Since their dynamic expansion could lead to neurological deterioration, their cellular-level and molecular analysis will provide valuable information. Proteomic and phosphoproteomic analysis in human TBI brains carried out in this study distinguished Ct, PC and away from contusion (AC). Mitochondrial dysfunction in AC could contribute to secondary injury events. Non-synaptic mitochondria displayed relatively more differentially expressed proteins compared to synaptosomes, while the latter revealed increased protein oxidation including tryptophan oxidation.Image contentThe image provided here highlights the blood brain barrier (BBB) alterations in the PC zone. A tissue section from the PC zone of human TBI brain stained with Luxol fast blue for myelin shows vasogenic edema with perivascular fluid accumulation from disrupted BBB.Read the full article‘Neuroanatomical zones of human traumatic brain injury reveal significant differences in protein profile and protein oxidation: Implications for secondary injury events ’ by N. Gowthami, N. Pursotham, G. Dey, V. Ghose, G. Sathe, N. Pruthi, D. Shukla, N. Gayathri, R. Santhoshkumar, B. Padmanabhan, V. Chandramohan, A. Mahadevan and M. M. Srinivas Bharath (J. Neur...
Source: Journal of Neurochemistry - Category: Neuroscience Tags: ISSUE INFORMATION Source Type: research