Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study

CONCLUSIONS: We show that cardiovascular and inflammatory biomarkers are altered in AAD compared with controls, particularly in women. RAGE might be a marker of disease severity in AAD, associated with more adrenal crises and reduced QoL. High ACTH reduced PDL2 and leptin levels in a glucocorticoid-independent manner but the overall effect on biomarker profiles was small.PMID:37807083 | DOI:10.1093/ejendo/lvad136

Source: European Journal of Endocrinology - October 8, 2023 Category: Endocrinology Authors: Åse Bjorvatn Sævik Grethe Ueland Anna-Karin Åkerman Paal Methlie Marcus Quinkler Anders Palmstr øm Jørgensen Charlotte H öybye Aleksandra W J Debowska Bj ørn Gunnar Nedrebø Anne Lise Dahle Siri Carlsen Aneta Tomkowicz Stina Therese Sollid Ingrid N Source Type: research