Parametric Imaging of P-Glycoprotein Function at the Blood –Brain Barrier Using kE,brain-maps Generated from [11C]Metoclopramide PET Data in Rats, Nonhuman Primates and Humans

ConclusionskE,brain of [11C]metoclopramide provides a simple outcome parameter to describe P-gp function in the living brain when arterial input function data are unavailable, although less sensitive thanVT.kE,brain-maps represent easy to compute parametric images reflecting the effect of P-gp on [11C]metoclopramide elimination from the brain.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research