Histopathologic features of biologic therapy nonresponders in chronic rhinosinusitis with nasal polyposis

ConclusionHistopathologic analysis of biologic nonresponders demonstrates decreased eosinophilia and thickened basement membranes. These findings, particularly low tissue eosinophils, are consistent with a non-type 2 CRSwNP that may be recalcitrant to biologic therapies. Histopathologic analysis done in conjunction with FESS may aid clinicians in understanding response to biologic therapies in patients with CRSwNP who have persistent symptom burden necessitating FESS.

https://onlinelibrary.wiley.com/doi/10.1002/alr.23283?af=R

Source: International Forum of Allergy and Rhinology - October 5, 2023 Category: Allergy & Immunology Authors: Ali M. Baird, Jamie Masliah, Peter Filip, Vidit Talati, Hannah J. Brown, Grant Owen, Sarah Khalife, Peter Papagiannopoulos, Paolo Gattuso, Pete S. Batra, Bobby A. Tajudeen Tags: ORIGINAL ARTICLE Source Type: research