P142 Accurate translation from Performance of Upper Limb (PUL) version 1.2 to 2.0 in Duchenne muscular dystrophy (DMD): a machine learning algorithm

The Performance of Upper Limb (PUL) module measures upper limb motor performance in ambulant and non-ambulant DMD. Two versions of the PUL exist: the originally developed version (PUL 1.2) and a revised version (PUL 2.0). While PUL 2.0 is currently in broader use in clinical trials and practice, prior studies contain extensive historical data on PUL 1.2. A cross-walk between PUL 1.2 and PUL 2.0 is needed to make full use of historical data, e.g., for contextualization of outcomes in clinical trials and across periods of natural history.

Source: Neuromuscular Disorders - October 1, 2023 Category: Neurology Authors: G. Coratti, E. Mercuri, G. Sajeev, A. Zhang, S. Ward, M. Pane, B. Vilma, J. Signorovitch Source Type: research