DLK1 overexpression improves sepsis-induced cardiac dysfunction and fibrosis in mice through the TGF- β1/Smad3 signaling pathway and MMPs

In conclusion, DLK1 expression was poorly expressed in the CLP-induced septic mouse heart. DLK1 overexpression partially alleviated sepsis-induced cardiac dysfunction and fibrosis, with the involvement of the TGF-β1/Smad3 signaling pathway and MMPs.
Source: Journal of Molecular Histology - Category: Laboratory Medicine Source Type: research