STING negatively regulates antifungal immunity

Trends Microbiol. 2023 Sep 22:S0966-842X(23)00264-0. doi: 10.1016/j.tim.2023.09.003. Online ahead of print.ABSTRACTDuring viral infections, stimulator of interferon genes (STING) exerts a positive protective immune response. Chen et al. now shed light on the distinct role of STING in fungal infections. STING translocates to the phagosome to negatively regulate the immune response against Candida albicans infection through the inhibition of Src-involved Syk phosphorylation.PMID:37741789 | DOI:10.1016/j.tim.2023.09.003

Source: Trends in Microbiology - September 23, 2023 Category: Microbiology Authors: Yebo Gu Xin-Ming Jia Source Type: research