Potential involvement of the bone marrow in experimental Graves ’ disease and thyroid eye disease

ConclusionCollectively, these data indicate that the bone marrow is activated in experimental Graves’ disease and TED, which is prevented by linsitinib. Linsitinib-mediated immune-inhibition is mediated, at least in part, by arginase-1 up-regulation, consumption of arginine and thereby immune inhibition.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research