NRF1 mitigates motor dysfunction and dopamine neuron degeneration in mice with Parkinson's disease by promoting GLRX m < sup > 6 < /sup > A methylation through upregulation of METTL3 transcription

CONCLUSION: Conclusively, NRF1 constrained motor dysfunction and dopamine neuron degeneration in MPTP-induced PD mice by activating the METTL3/GLRX axis.PMID:37735974 | DOI:10.1111/cns.14441

Source: CNS Neuroscience and Therapeutics - September 22, 2023 Category: Neuroscience Authors: Xin Gong Mengyi Huang Lei Chen Source Type: research