Characterisation of common genetic variants in P2RX7 and their contribution to chronic pain conditions
In this study, we first systematically characterized all 17 common nonsynonymous variants using whole-cell patch clamp electrophysiology. Then, we analyzed these variants for statistical association with chronic pain phenotypes using both individual P2RX7 variants as predictors and cumulative allele counts of same-direction cellular effect in univariate models.
Source: The Journal of Pain - Category: Materials Science Authors: Katerina Zorina-Lichtenwalter, Ariel R. Ase, Vivek Verma, Arturo I.M. Parra, Svetlana Komarova, Anmar Khadra, Philippe S éguéla, Luda Diatchenko Tags: Original Reports Source Type: research