Characterisation of common genetic variants in P2RX7 and their contribution to chronic pain conditions

In this study, we first systematically characterized all 17 common nonsynonymous variants using whole-cell patch clamp electrophysiology. Then, we analyzed these variants for statistical association with chronic pain phenotypes using both individual P2RX7 variants as predictors and cumulative allele counts of same-direction cellular effect in univariate models.
Source: The Journal of Pain - Category: Materials Science Authors: Tags: Original Reports Source Type: research