CHIP in HF: prognostic role and cell-intrinsic effects

Nature Reviews Cardiology, Published online: 20 September 2023; doi:10.1038/s41569-023-00942-7Two studies now report that TET2-driven clonal haematopoiesis of indeterminate potential (CHIP) is associated with poor prognosis in patients with heart failure (HF) and preserved ejection fraction and that DNMT3A CHIP driver mutations promote dysregulated gene expression profiles that are associated with inflammation in monocytes in the setting of HF.
Source: Nature Reviews Cardiology - Category: Cardiology Authors: Source Type: research