Absorption of an Engineered Medium Chain Fatty Acid Analogue in Two Short Bowel Syndrome Minipig Models

CONCLUSION: In two SBS-IF minipig models, SEFA-6179 had substantially decreased absorption compared to pre-resection minipigs. Dose optimization for different intestinal anatomy and function may be required. We describe a new SBS-IF pseudojejunostomy model that may improve the translation of preclinical research to SBS-IF patients with enterostomies. This article is protected by copyright. All rights reserved.PMID:37726175 | DOI:10.1002/jpen.2563

Source: JPEN Journal Of Parenteral And Enteral Nutrition - September 19, 2023 Category: Nutrition Authors: Scott C Fligor Savas T Tsikis Thomas I Hirsch Amy Pan Paul D Mitchell Mikayla Quigley Sarah Carbeau Arthur Nedder Kathleen M Gura Mark Puder Source Type: research