Effects of a new selective β3‐adrenoceptor agonist, vibegron, on bladder and urethral function in a rat model of Parkinson's disease

ConclusionsThe results of the present study provide corroborating evidence that bladder dysfunction is suppressed by the administration of vibegron in Parkinson's disease model rats, confirming that vibegron is effective for treating overactive bladder without further worsening urethral function. These findings may contribute to a better understanding of the mechanisms of β3-adrenoceptor agonists.

Source: LUTS: Lower Urinary Tract Symptoms - September 19, 2023 Category: Urology & Nephrology Authors: Mio Togo, Takeya Kitta, Hiroki Chiba, Madoka Higuchi, Naohisa Kusakabe, Mifuka Ouchi, Yui Abe ‐Takahashi, Hidehiro Kakizaki, Nobuo Shinohara Tags: ORIGINAL ARTICLE Source Type: research