The mTOR Inhibitor Rapamycin Counteracts Follicle Activation Induced by Ovarian Cryopreservation in Murine Transplantation Models

Conclusions: By adding rapamycin during the OTCTP procedure, we were able to transiently maintain primordial follicles in a quiescent state. This is a promising method for improving the longevity of the ovarian graft. Furthermore, both the ear and kidney capsule transplantation models were suitable for investigating follicle activation and proliferation and pharmacological strategies.PMID:37629764 | PMC:PMC10456585 | DOI:10.3390/medicina59081474

Source: Medicina (Kaunas) - August 26, 2023 Category: Universities & Medical Training Authors: Jules Bindels Marlyne Squatrito La ëtitia Bernet Michelle Nisolle Laurie Henry Carine Munaut Source Type: research