Prolonged course of eravacycline leading to acute pancreatitis

We describe a 46-year-old male who received eravacycline for treatment of a perirectal abscess. While the patient had slightly elevated lipase levels at baseline post-cardiopulmonary arrest, he developed abdominal pain and a further increase in lipase levels following 10 days of eravacycline, consistent with pancreatitis. Based on the Naranjo adverse drug reaction probability scale, eravacycline was the probable etiology of acute pancreatitis given improvement immediately after discontinuation. Clinicians should be aware of this potential adverse effect of eravacycline and should not initiate eravacycline in those with risk factors for acute pancreatic injury. However, acute pancreatitis should be suspected in all patients complaining of symptoms followed by immediate discontinuation of eravacycline.PMID:37716601 | DOI:10.1016/j.amjms.2023.09.012

Source: The American Journal of the Medical Sciences - September 16, 2023 Category: General Medicine Authors: Sylvia Stefanos Lyndsey Davis Amruta Panwala Michael S Gelfand Chinelo N Animalu B Tate Cutshall Source Type: research