Decreased plasma levels of sphingolipids and total cholesterol in adult cystic fibrosis patients

Cystic fibrosis (CF) is the most common genetic disorder in Caucasian population. It is an autosomal recessive disease characterized by a defect in the epithelial membrane chloride channel later named cystic fibrosis transmembrane conductance regulator (CFTR). The mutations in CFTR result with an impaired ciliary function in the lungs with recurrent bacterial infections in CF patients [1]. As a result of the acute infections and chronic inflammation, obstructive lung disease becomes the major cause of morbidity and mortality in these patients.

Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - September 16, 2023 Category: Biomedical Science Authors: Dilara BAL Topcu, Berrin Er, Filiz Ozcan, Mutay Aslan, Lutfi Coplu, Incilay Lay, Yesim Oztas Tags: Original research article Source Type: research