Design, semi-synthesis, anti-cancer assessment, docking, MD simulation, and DFT studies of novel theobromine-based derivatives as VEGFR-2 inhibitors and apoptosis inducers

In conclusion, our in vitro and in silico investigations showed that compound 15 exhibited promising apoptotic anticancer potential through the suppression of VEGFR-2.PMID:37673011 | DOI:10.1016/j.compbiolchem.2023.107953

Source: Computational Biology and Chemistry - September 6, 2023 Category: Bioinformatics Authors: Ibrahim H Eissa Reda G Yousef Hazem Elkady Eslam B Elkaeed Aisha A Alsfouk Dalal Z Husein Ibrahim M Ibrahim Mostafa A Elhendawy Murrell Godfrey Ahmed M Metwaly Source Type: research