Paramagnetic rim and core sign lesions in paediatric multiple sclerosis patients

Introduction In the last years, susceptibility-weighted imaging (SWI) has been applied in multiple sclerosis (MS) to identify a subgroup of white matter lesions (WMLs) characterised by a hypointense rim (ie, paramagnetic rim lesions (PRL)). Correlative pathological-MRI studies have shown that these lesions, defined as chronic active, are characterised by a peripheral ‘rim’ of iron-laden activated microglia/macrophages associated with ongoing demyelination and axonal loss.1 A subset of WMLs showing a diffuse hypointensity on SWI (ie, core sign lesions) has also been recently described.2 These lesions have been suggested to reflect acute inflammation showing widespread demyelination and infiltrates of activated microglia/macrophages.2 PRLs are considered relatively specific for MS, are present across all adult MS phenotypes and predict a more severe disease evolution.1–3 On the other hand, core sign lesions have been observed at the earliest phases of adult...
Source: Journal of Neurology, Neurosurgery and Psychiatry - Category: Neurosurgery Authors: Tags: PostScript Source Type: research